A Case Study Report: Zoledronic Acid Induced Jaw Osteonecrosis in Patient with Bone Metastasis, A Relatively Rare Side Effect

Abstract

Jaw osteonecrosis (JON) is an extraordinary reaction seen in sufferers receiving bisphosphonate remedy for bone retention for the duration of cases of bone metastasis. Nitrogen-based totally bisphosphonates (NBBP) similar to Zoledronic acid whilst injected with intravenous (IV) have a stronger potential to enhance jaw osteonecrosis in comparison with oral treatment. To get the fine healing consequences and to be affected person, it's miles best to apply zoledronic acid every year. This paper reviews the case of an eighty-year-vintage woman affected by endometrial cancer with bone metastasis advanced through Jaw osteonecrosis (JON) after consecutive cycles to offer her Zoledronic acid. Exam reveals early signs and symptoms of Jaw osteonecrosis (JON) in a doctor's record she became tested and discontinued giving zoledronate. Jaw osteonecrosis (JON) happens due to zoledronate perennial infusions. The chance increases for humans with bad oral hygiene due to infections.