Abstract
Background: Duchenne Muscular Dystrophy (DMD) is a progressive X-linked neuromuscular disorder characterized by the absence of dystrophin, leading to muscle degeneration, weakness, and loss of functional abilities. While physical activity is essential to maintain strength and function, high-intensity exercise may accelerate muscle damage. Blood Flow Restriction training has emerged as a potential low-load alternative to safely enhance muscle performance in individuals with neuromuscular conditions. To evaluate the effectiveness of moderate-intensity resistance training combined with blood flow restriction in improving muscle strength in late non-ambulatory DMD patient.
Case Presentation: A single case study was conducted on a 9-year-old male with late non-ambulatory DMD (Stage 4, Brooke Functional Rating Scale). The intervention consisted of a 3-week moderate-intensity resistance training program combined with BFR, administered three times per week for 40 minutes. Exercises targeted upper and lower limb muscle groups using elastic bands and weight cuffs at 50% of maximum voluntary contraction. The Motor function measurement 36 scale were used as outcome measures to assess muscle strength.
Conclusion: post-intervention findings demonstrated measurable improvements in upper and lower limb muscle strength and enhanced MFM 36 scores across physical, emotional, and social domains, indicating better overall functional performance and Improved strength. Moderate-intensity resistance training combined with blood flow restriction appears to be a safe and effective approach for improving muscle strength and quality of life in late non-ambulatory Duchenne Muscular Dystrophy patients. This case highlights the potential of BFR-assisted physiotherapy as an adjunct rehabilitation strategy in progressive neuromuscular disorders.