https://shareme.joinjet.org/ojs/index.php/shareme <p>SHAREme- Scientific Hub of Applied Research in Emerging Medical science &amp; technology is a leading international journal for publication of new ideas, the state of the applied research results and fundamental advances in all aspects of Medical Science and technology started in 2022. SHAREme is a scholarly open access, peer reviewed international journal with a primary objective to provide the academic community and industry for the submission of their original research.<br /><strong>Publication fee Rs.2000</strong></p> Jegathambal Research Foundation en-US Scientific Hub of Applied Research in Emerging Medical science & technology 2583-3162 https://shareme.joinjet.org/ojs/index.php/shareme/article/view/115 <p><strong>Background: </strong>Levofloxacin, a broad-spectrum fluoroquinolone antibiotic, demonstrates optimal therapeutic efficacy when absorbed in the upper gastrointestinal tract (GIT). Conventional oral formulations of levofloxacin are limited by rapid gastric transit, which reduces drug bioavailability. Gastroretentive floating microspheres represent a promising strategy to prolong gastric residence time (GRT) and achieve controlled drug release.</p> <p><strong>Objective: </strong>The present study aimed to develop and evaluate levofloxacin-loaded floating microspheres employing Eudragit RS100 and ethyl cellulose as polymeric carriers, using the emulsion solvent diffusion technique, to achieve sustained drug release and enhanced buoyancy.</p> <p><strong>Methods: </strong>Four formulations (F1–F4) were prepared at drug-to-polymer ratios of 1:1 and 1:2 using Eudragit RS100 and ethyl cellulose in dichloromethane. Polyvinyl alcohol (1% w/v) served as the aqueous emulsifying phase. Formulations were evaluated for particle size, percentage yield, drug entrapment efficiency, floating behavior, scanning electron microscopy (SEM), FTIR compatibility, in vitro drug release in pH 1.2 HCl buffer, and short-term stability.</p> <p><strong>Results: </strong>Optimized formulation F3 (Eudragit RS100; drug: polymer (1:1) demonstrated a mean particle size of 160 µm, drug entrapment efficiency of 82.39%, and buoyancy exceeding 8 hours. In vitro release studies confirmed a sustained-release profile with 97.89% cumulative drug release over 8 hours. FTIR analysis confirmed the absence of drug–excipient interactions, and SEM revealed smooth, spherical morphology. Stability studies at 25°C, 30°C, and 40°C over 90 days indicated no significant changes in drug release or physical characteristics.</p> <p><strong>Conclusion: </strong>Floating microspheres of levofloxacin prepared by the emulsion solvent diffusion method exhibited desirable gastroretentive, physicochemical, and sustained-release properties. Eudragit RS100-based formulation F3 emerged as the optimal candidate for gastroretentive controlled drug delivery.</p> Madhuri Yaramalla Anjali Appala S. S Prasanna Kumar Ponnaganti Saikrishna N Copyright (c) 2026 2026-07-09 2026-07-09 5 3 470 477 https://shareme.joinjet.org/ojs/index.php/shareme/article/view/116 <p>Musculoskeletal disorders are a significant occupational health concern among healthcare professionals worldwide, including in India. Therefore, it is important to conduct a systematic review to determine the prevalence of musculoskeletal disorders specifically among healthcare professionals in the Indian population.</p> <p>This study aims to analyse the factors related to knowledge, perceptions, and attitudes of health professionals with occupational safety and health behaviour in order to gain a better understanding of the prevalence and impact of musculoskeletal disorders in this population.</p> <p>The systematic review will follow the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, taking into account relevant studies on the prevalence and risk factors of musculoskeletal disorders among healthcare professionals in India. The search for relevant studies was conducted using databases such as PubMed, Scopus, PsycINFO, Global Health, Web of Science, CINAHL, Google Scholar, and Research Gate. This approach will ensure a comprehensive review of the available literature on this topic.</p> <p>Therefore, this systematic review will provide valuable insights into the prevalence and risk factors of musculoskeletal disorders in this specific population.</p> <p>In conclusion, this systematic review aims to fill the gap in knowledge regarding the prevalence of musculoskeletal disorders among healthcare professionals in India. The findings of this study will contribute to a better understanding of the extent of musculoskeletal disorders in the Indian healthcare workforce, which can inform strategies and interventions aimed at preventing and managing these disorders.</p> <p>This systematic review will also provide a thorough analysis of the available literature in order to determine the prevalence and risk factors of musculoskeletal disorders among healthcare professionals in India. To conduct this systematic review, we will adhere to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.</p> Mercy Thomas S. Jeyakumar N. Senthil Kumar Sarah John Thomas Copyright (c) 2026 2026-07-09 2026-07-09 5 3 478 484 https://shareme.joinjet.org/ojs/index.php/shareme/article/view/117 <p class="BT" style="text-indent: 0cm; margin: 5.0pt 1.0cm .0001pt 1.0cm;">Moderate-Intensity Continuous Training (MICT) has traditionally been used as the standard exercise method in cardiac rehabilitation programs. However, High-Intensity Interval Training (HIIT) has recently gained attention as a potentially more effective approach.</p> <p class="BT" style="text-indent: 0cm; margin: 5.0pt 1.0cm .0001pt 1.0cm;">The purpose of this review is to compare the effectiveness and safety of HIIT and MICT in improving aerobic capacity and functional performance in patients with chronic heart failure. A systematic search of literature published between 2016 and 2025 was conducted using databases such as Google Scholar and Research Gate. Studies were screened using PRISMA guidelines and their methodological quality was assessed using the PEDro scale.</p> <p class="BT" style="text-indent: 0cm; margin: 5.0pt 1.0cm .0001pt 1.0cm;">Most of the reviewed studies reported that HIIT produced greater improvements in aerobic capacity and functional mobility when compared to MICT. When performed under proper supervision, HIIT was also found to be safe for stable CHF patients</p> Mudita Sawant Nisha Gupta Vasu Singh Copyright (c) 2026 2026-07-12 2026-07-12 5 3 478 482